Metabolic Profiling Spectrabase

Streamlined Metabolite Analysis and Identification

The Metabolic Profiling Database is designed for metabolite identification and quantification in NMR-based metabolic profiling. This new reference database was developed through a collaboration between Bruker BioSpin and major food and pharmaceutical companies and leading universities in the field of metabonomics. It contains information on the most common endogenous metabolites in body fluids (urine, blood, cerebral spinal fluid), and known metabolites of some over-the-counter drugs and selected food components. The entries represent comprehensive NMR data for the metabolites, and each is measured at a number of different pH levels.

The new Metabolic Profiling Database enables NMR researchers to accurately and more quickly identify and quantitate compounds and make on-the-fly decisions during measurements. The database interfaces with either Bruker BioSpin’s TopSpin® or AMIX™ software platforms. The database’s structure and software also enable users to add their own proprietary compounds—a valuable feature in drug and disease research.

The database augments the integrated Metabolic Profiler™ platform from Bruker BioSpin and Bruker Daltonics, a system that combines NMR with time-of-flight (TOF) mass spectrometry, for data acquisition, analysis, and statistical model building. The Metabolic Profiler system is particularly applicable to toxicity and efficacy studies in pre-clinical and clinical development in the pharmaceutical and biotech industries as well as in clinical research.