Flow NMR Probes

Bruker BioSpin has developed a variety of high-resolution flow NMR probes:

• LC probes with optimized flow cell size for chromatographic peaks and minimized band broadening during sample transfer.
• FI probes optimized for high sample throughput.

Both types of flow probes have a built-in NMR flow cell, which delivers the following advantages:

• The geometry of the RF coils, together with a fixed flow cell, provide higher NMR sensitivity in comparison to standard tube probes due to an improved filling factor.
• Sample preparation like shimming is minimized or even not necessary, as only the sample solution itself is exchanged.
• Preparation of samples in NMR tubes is no longer necessary, eliminating consumption of expensive NMR tubes.

The seamless link of the flow probe to a chromatography system or a liquid handler allows for direct transfer of the sample into the NMR probe. This direct transfer offers:

• Minimized sample handling and thus minimized danger of contamination and decomposition of samples.
• Highest speed and level of automation from sample preparation to NMR measurement.
• The probe is the only modification necessary to convert a standard NMR spectrometer for flow applications and backwards. The probe change can be done in minutes.

The properties for the available flow probes include:

• A field strength of 300-900 MHz.
• Available flow cell sizes of 30, 60 and 120 µl.
• The NMR configuration is available as a SEI probe, a TXI or a DXI (1H/19F) probe.
• Available with Z- or XYZ gradients, BTO and ATMA.
• Compatible with all HR-NMR spectrometers.